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KMID : 0387820180250010043
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Clinical Pediatric Hematology-Oncology
2018 Volume.25 No. 1 p.43 ~ p.49
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Childhood Venous Thromboembolism in Yeungnam Region in Korea: Multicenter Study
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Lee So-Ram
Youn Jong-Hyuk
Lim Jae-Young
Chueh Hee-Won
Lee Jae-Min
Suh Jin-Kyung
Kim Ji-Yoon
Yang Eu-Jeen
Park Kyung-Mi
Lim Young-Tak
Park Ji-Kyoung
Choi Eun-Mi
Shim Ye-Jee
Kim Heung-Sik
Park Sang-Kyu
Kong Seom-Kim
Choi Eun-Jin
Park Eun-Sil
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Abstract
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Background: Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it’s incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors, and prognosis of pediatric patients with VTE in Korea.
Methods: Between January 2000 and July 2017, 249,312 medical records of the patients older than 1 year who were hospitalized in the department of pediatrics of 10 university hospitals in Yeungnam region were retrospectively reviewed.
Results: The overall incidence of VTE was 4.9 per 10,000 admissions. Of the total 123 patients, 80 (65.0%) were male and the median age was 10.8 years (range, 1.0-23.5 years). Magnetic resonance imaging was performed most frequently to confirm the diagnosis of VTE (43.1%). Thrombosis occurred in the cerebral vessels (46.3%), lower extremities (23.8%), pulmonary (19.5%), abdomen (9.8%), and upper extremities (4.1%). One hundred and six patients had underlying causes such as cancer (27.6%), infection (26.8%), intravenous catheter insertion (17.9%), and surgery (14.6%). Protein C was evaluated in 39 patients (31.7%), protein S in 40 (32.5%), antithrombin (AT) III in 52 (42.3%), and homocysteine in 21 (17.1%). Among them, one patient with a family history of AT III deficiency had SERPINC gene mutation. Seventy-seven patients (62.6%) started anti-coagulation treatment. Most (52.0%) were treated for more than 90 days.
Conclusion: Healthcare providers must be aware of the potential for VTE development in childhood. In the near future, a nationwide survey should be investigated to determine the incidence rate and the trends in VTE among Korean children.
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KEYWORD
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Venous thromboembolism, Pediatric patients, Epidemiology
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