KMID : 0387820180250010043
|
|
Clinical Pediatric Hematology-Oncology 2018 Volume.25 No. 1 p.43 ~ p.49
|
|
Childhood Venous Thromboembolism in Yeungnam Region in Korea: Multicenter Study
|
|
Lee So-Ram
Youn Jong-Hyuk Lim Jae-Young Chueh Hee-Won Lee Jae-Min Suh Jin-Kyung Kim Ji-Yoon Yang Eu-Jeen Park Kyung-Mi Lim Young-Tak Park Ji-Kyoung Choi Eun-Mi Shim Ye-Jee Kim Heung-Sik Park Sang-Kyu Kong Seom-Kim Choi Eun-Jin Park Eun-Sil
|
|
Abstract
|
|
|
Background: Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it¡¯s incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors, and prognosis of pediatric patients with VTE in Korea.
Methods: Between January 2000 and July 2017, 249,312 medical records of the patients older than 1 year who were hospitalized in the department of pediatrics of 10 university hospitals in Yeungnam region were retrospectively reviewed.
Results: The overall incidence of VTE was 4.9 per 10,000 admissions. Of the total 123 patients, 80 (65.0%) were male and the median age was 10.8 years (range, 1.0-23.5 years). Magnetic resonance imaging was performed most frequently to confirm the diagnosis of VTE (43.1%). Thrombosis occurred in the cerebral vessels (46.3%), lower extremities (23.8%), pulmonary (19.5%), abdomen (9.8%), and upper extremities (4.1%). One hundred and six patients had underlying causes such as cancer (27.6%), infection (26.8%), intravenous catheter insertion (17.9%), and surgery (14.6%). Protein C was evaluated in 39 patients (31.7%), protein S in 40 (32.5%), antithrombin (AT) III in 52 (42.3%), and homocysteine in 21 (17.1%). Among them, one patient with a family history of AT III deficiency had SERPINC gene mutation. Seventy-seven patients (62.6%) started anti-coagulation treatment. Most (52.0%) were treated for more than 90 days.
Conclusion: Healthcare providers must be aware of the potential for VTE development in childhood. In the near future, a nationwide survey should be investigated to determine the incidence rate and the trends in VTE among Korean children.
|
|
KEYWORD
|
|
Venous thromboembolism, Pediatric patients, Epidemiology
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|